Eastell R, Boyle IT, Compston J et al. Management of male osteoporosis: report of the UK Consensus Group. Q J Med. Eastell R. Treatment of postmenopausal osteoporosis. N Engl J Med. Connell MB. Prevention and treatment of osteoporosis in the elderly. Pharmacotherapy. 1999; 19Suppl.
Kanis JA, Oden A, Johansson H et al. FRAX and its applications to clinical practice. Bone. This drug may also be prescribed once weekly for osteoporosis. Check your prescription label carefully, and ask your doctor or pharmacist if you are not sure how to take this medication. Talk to your doctor about the risks and benefits of long-term use of this medication. Take this by with food. Have you seen a rheumatologist for this condition?
Studies of Hycodan in animals to evaluate the carcinogenic and mutagenic potential and the effect on fertility have not been conducted. Fosamax years ago for Osteopenia. Bone density exams showed improvement. After being on the drug for over five years studies came out suggesting that taking Fosamax for over five years was not a good idea. My GYN and I decided to take a break. A couple years after that I was struck with a nasty case of Sciatica. NOTHING helped. shots. pills. acupuncture. physical therapy. homeopathy that demonstrates my desperation. For over a year and a half I was bedridden on powerful pain medication trying to keep up with raising my twins who are both neurologically and developmentally "disabled" most of the work is navigating the system and fighting bureaucracies. These two people are amazingly bright, talented and have wonderful hearts. The problem is not they; it's.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Talk with your doctor before you drink alcohol, smoke, or use other tobacco products while taking Fosamax. If you are taking the chewable form of this medication, chew thoroughly before swallowing. If you are taking capsules, swallow each capsule whole. Do you take any vitamins or supplements?
Ask your health care provider any questions you may have about how to use Fosamax. Known risk factors include cancer, chemotherapy, radiation therapy, corticosteroids, poor oral hygiene, preexisting dental disease, anemia, coagulopathy, and infection. Osteoporosis Society of Canada Scientific Advisory Board. Clinical practice guidelines for diagnosis and management of osteoporosis. CMAJ. Certain fractures of the thigh bone femur have been reported in patients using bisphosphonates. It is unknown if bisphosphonates contributed to the fractures. Contact your doctor right away if you experience hip, thigh, or groin pain. Discuss any questions or concerns with your doctor. Ipriflavone is a product made in a laboratory from one of the isoflavones found in soy. When combined with calcium, ipriflavone appears to prevent bone loss and reduce pain associated with compression fractures in the spine. Fosamax should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. Fosamax Plus D is usually taken 1 time each week. Be sure you understand how to take Fosamax Plus D. Contact your doctor or pharmacist if you have any questions. Intravenous increases blood levels of alendronate. During this time, bone mass is lost faster. National Institute of Dental and Craniofacial Research: "TMJ Disorders. Follow the diet and exercise program given to you by your health care provider. Surgery is scary for just about anyone. I do know people who have had this surgery done when things had become unbearable. They always say later that they ought not to have waited so long. What are the doctors saying for a time table for you? Rosen CJ, Kessenich CR. Comparative clinical pharmacology and therapeutic use of bisphosphonates in metabolic bone diseases. Drugs. Body frame size. Men and women who have small body frames tend to have a higher risk because they may have less bone mass to draw from as they age. Hycodan tablets also contain: calcium phosphate dibasic, colloidal silicon dioxide, lactose, magnesium stearate, starch and stearic acid. Co. Inc. under the brand name Fosamax, works by preventing bone resorption, which is essentially when bone is being removed without being replaced.
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Adachi JD, Bensen WG, Brown J et al. Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis. N Engl J Med. Osteoporosis affects men and women of all races. WHY hasn't the maker of Fosamax made this side effect public? But much higher levels are better, says guideline committee chairman Michael F. Holick, MD, PhD, director of the vitamin D and bone research lab at Boston University. Roux C, Oriente P, Laan R et al. Randomized trial of effect of cyclical etidronate in the prevention of corticosteroid-induced bone loss. J Clin Endocrinol Metab. Stock JL, Bell NH, Chestnut CH et al. Increments in bone mineral density of the lumbar spine and hip and suppression of bone turnover are maintained after discontinuation of alendronate in postmenopausal women. Am J Med. Alendronate 10 mg once daily or 70 mg once weekly in men and postmenopausal women. Hydrocodone can produce drug dependence of the morphine type and, therefore, has the potential for being abused.
Do I need to be screened for osteoporosis? Cant do any of the things I used to. The above symptoms aren't the only ones that I've experienced, just had so many cant remember them all by now. This medication is used to treat certain types of bone loss osteoporosis and to increase bone mass. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases as you age, after menopause, or if you are taking corticosteroid medications such as prednisone for a long time. This information should not be used to decide whether or not to take Fosamax or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Fosamax. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Fosamax. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Fosamax. Few foods carry much vitamin D other than salmon and mackerel. Milk and some orange juice is fortified with small doses. Evaluate patients who present with new thigh or groin pain for possibility of an atypical femoral fracture; include assessment of the contralateral limb. 89 90 91 93 94 Consider interruption of bisphosphonate therapy in patients with manifestations of possible femoral fracture; weigh risks versus benefits of continued treatment. 89 90 Discontinue if a femoral shaft fracture is confirmed. Bone says. "That lets formation catch up with resorption and helps stabilize the bone. Did they do the spine as well? Injection versions of the drugs appear to carry a higher risk. The risk of osteonecrosis is generally thought to be quite low for oral bisphosphonates. Have you noticed a loss of height? European Foundation for Osteoporosis and Bone Disease, National Osteoporosis Foundation, and National Institute of Arthritis and Musculoskeletal and Skin Diseases. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. Tell your doctor or dentist that you take Fosamax Plus D before you receive any medical or dental care, emergency care, or surgery. How often do you exercise?
How can I best manage them together? Store products except alfacalcidol at room temperature away from light and moisture. not store in the bathroom. Store alfacalcidol drops in the refrigerator between 36-46 degrees F 2-8 degrees C. Do not freeze. Keep all away from children and pets. Do I need a prescription for alendronate? Bisphosphonates. These include ibandronate Boniva risedronate and Reclast. If it has acetaminophen, count it toward your daily limit. Postmenopausal women who had been on hormone therapy to protect their bones flooded doctors' offices in search of an alternative, Miller said. Cummings SR, Black DM, Thompson DE et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures. JAMA. Animal reproduction studies have not been conducted with Hycodan. It is also not known whether Hycodan can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Hycodan should be given to a pregnant woman only if clearly needed. Denosumab . It's used to treat people who are at high risk for bone related to decreased bone density. We now have some excellent drugs for bone loss.
Tucci JR, Tonino RP, Emkey RD et al. Effect of three years of oral alendronate treatment in postmenopausal women with osteoporosis. Am J Med. Eli Lilly and Company. Evista raloxifene hydrochloride tablets prescribing information. Merck. Fosamax alendronate sodium tablets patient information. West Point, PA; 1997 Apr. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day if you are taking it once a day. If you are taking this medication only once a week, remember to take it on the same day each week. It may help to mark your calendar with a reminder. The recommended initial dosage is one 70 mg molar equivalent tablet or oral liquid bottle once weekly or one 10 mg molar equivalent tablet per day. Fosamax must be taken at least one-half hour before the first food, beverage, or medication of the day with plain water only to avoid any reduction in gastrointestinal adsorption. Fosamax may interact with aspirin or other NSAIDs non-steroidal anti-inflammatory drugs. Tell your doctor all medications and supplements you use. There are no studies in pregnant or nursing women. Fosamax is not indicated for use in the pediatric population. Take this medication by mouth, after getting up for the day and before taking your first food, beverage, or other medication. Take it with a full glass 6-8 ounces or 180-240 milliliters of plain water. Swallow the tablet whole. Do not chew or suck on it. Then stay fully upright sitting, standing, or walking for at least 30 minutes and do not lie down until after your first food of the day. Alendronate works only if taken on an empty stomach. Wait at least 30 minutes preferably 1 to 2 hours after taking the medication before you eat or drink anything other than plain water. Alendronate is widely distributed after oral administration. 114 Subsequently, redistributes rapidly to skeletal tissues. Recent research has shown that women who lose bone density after the first year of menopausal will gain bone density in the next two years, whereas women who gain in the first year will tend to lose density in the next two years of therapy. Therefore, bone density during treatment naturally fluctuates and this may not be relevant to the fracture protection of the medication. The FDA convened the meeting because of emerging safety concerns related to long-term use -- generally considered more than three to five years -- of bisphosphonates. If you have any questions about Fosamax, please talk with your doctor, pharmacist, or other health care provider. In a written reply to WebMD, Wysowski noted that patients who take bisphosphonates should make sure they take the drugs as directed, first thing in the morning with a full glass of water at least 30 minutes to an hour before eating, drinking anything other than water, or taking other medications. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Registered Trademark of Endo Pharmaceuticals Inc. Saag KG, Emkey R, Schnitzer TJ et al. Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. New Engl J Med. Choose the day of the week that best fits your schedule.
Abdominal pain, acid regurgitation, constipation, diarrhea, dyspepsia, musculoskeletal pain, nausea. Before prescribing medication to suppress or modify cough, it is important to ascertain that the underlying cause of cough is identified, that modification of cough does not increase the risk of clinical or physiological complications, and that appropriate therapy for the primary disease is provided. Swallow Fosamax whole. Do not break, crush, chew, or suck on the tablet before swallowing. She succeeded in eliminating the Sciatica. Somewhere during all this horrendous ordeal, another bone density exam showed deterioration resulting in osteoporosis, mostly the right femur neck. Went back on the Fosamax a bit before the acupuncturist vanquished the Sciatica. When the Sciatica was gone, I was ecstatic for a minute but realized I was still in horrible pain. Different pain. Lower back, hips, waist, spine. Rossini M, Gatti D, Zamberlan N et al. Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis. J Bone Miner Res. Best advice - ALWAYS GET A SECOND OPPINION! Nausea and vomiting may occur; they are more frequent in ambulatory than in recumbent patients. Prolonged administration of Hycodan may produce constipation. If you think you may have a serious medical problem, get medical help right away. Reclast, and -- may raise the risk of thigh bone fracture, the FDA warns. Waiting less than 30 minutes, or taking FOSAMAX PLUS D with food, beverages other than plain water or other medications will lessen the effect of alendronate by decreasing its absorption into the body. What the evidence does show is that vitamin D helps the body use to prevent and to build stronger bones, and that vitamin D prevents falls in the elderly by improving muscle function. But Actonel works faster, a study by top experts suggests. Fosamax may cause jawbone problems in some patients. Your risk may be greater the longer you take Fosamax or if you have cancer, poor dental hygiene, ill-fitting dentures, or certain other conditions eg, anemia, blood clotting problems, dental problems, infection. Your risk may also be greater if you have certain dental procedures or you use certain medicines or therapies eg, chemotherapy, corticosteroids, radiation. Talk to your doctor about having a dental exam before you start to use Fosamax. Ask your doctor any questions you may have about dental treatment while you use Fosamax.
Exercise can help you build strong bones and slow bone loss. Exercise will benefit your bones no matter when you start, but you'll gain the most benefits if you start exercising regularly when you're young and continue to exercise throughout your life. Have you experienced any fractures or broken bones? Many people using this medication not have serious side effects. Watts tells WebMD. "We found a significantly lower rate of fracture at hip and non-vertebral sites for patients given Actonel vs. Fosamax at both six and 12 months. Fosamax Plus D may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Fosamax Plus D with caution. If any of these effects persist or worsen, tell your doctor or promptly. Wysowski DK, Chang JT. Alendronate and risedronate: reports of severe bone, joint, and muscle pain. Arch Intern Med. EXCRUCIATING FACIAL PAIN. BONE DEATH OF THE JAW, AND LAST BUT NOT LEAST WOKE UP ONE MORNING TO FIND MYSELF COMPLETELY PARALYZED FROM NECK DOWN AND COULD NOT GET OUT OF BED. Take FOSAMAX upon arising for the day. To facilitate delivery to the stomach and thus reduce the potential for esophageal irritation, a FOSAMAX tablet should be swallowed with a full glass of water 6-8 ounces. To facilitate gastric emptying FOSAMAX oral solution should be followed by at least 2 ounces a quarter of a cup of water. Patients should not lie down for at least 30 minutes and until after their first food of the day. FOSAMAX should not be taken at bedtime or before arising for the day. Fosamax Plus D should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. Hydrocodone is a semisynthetic opioid antitussive and analgesic with multiple actions qualitatively similar to those of codeine. The precise mechanism of action of hydrocodone and other opiates is not known; however, hydrocodone is believed to act directly on the cough center. In excessive doses, hydrocodone, like other opium derivatives, will depress respiration. The effects of hydrocodone in therapeutic doses on the cardiovascular system are insignificant. Hydrocodone can produce miosis, euphoria, physical and physiological dependence. But both of these top doctors point out that not all women are equal. Some women may tolerate one drug better than another. Or their may pay more for one than the other. The new treatment guidelines point to new data suggesting that the IOM recommendations "may be inadequate. Harris ST, Gertz BJ, Genant HK et al. The effect of short term treatment with alendronate on vertebral density and biochemical markers of bone remodeling in early postmenopausal women. J Clin Endocrinol Metab. See Food under Pharmacokinetics.
It's possible for these fractures to occur in patients who are not taking bisphosphonates, Sandra Kweder, MD, deputy director of the FDA's office of new drugs, said at a news teleconference. This medication is usually taken once per week unless otherwise directed by your doctor. Choose the day of the week that best fits your schedule and take it on that day each week. My mother had such severe osteoporosis that her bones were down to a lace-like structure by the time she died. She could be sitting still in a chair and have ribs break. She was on morphine so much in the last couple of years that her personality changed. I know first-hand that's not a fate I want to experience, but destroying the current quality of my life to prevent that outcome doesn't make any sense either. The respiratory depression properties of opioids and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Furthermore, opioids produce adverse reactions which may obscure the clinical course of patients with head injuries. Reclast, Skelid, and Zometa. 2008 Jan 7. Available from FDA website. Watts is quick to point out that the study is not a clinical trial and therefore cannot be taken as conclusive proof. What treatments are available, and which do you recommend? Available as alendronate sodium; dosage expressed in terms of alendronate. Preventive Services Task Force. Postmenopausal hormone replacement therapy for primary prevention of chronic conditions: recommendations and rationale.
Bisphosphonate labels mention that safety and effectiveness information is based on one to four years -- depending on the drug -- of data, Kehoe said, but optimal length of use is unknown. Proper dental care is important while you are taking Fosamax Plus D. Brush and floss your teeth and visit the dentist regularly. The agency's own analysis concluded that in women who continue bisphosphonate therapy after five years of use there's no clear benefit or evidence of harm and no subset of patients who have a "clear and consistent" reduced fracture risk, FDA scientist Theresa Kehoe, MD, told the panel. Alendronate incorporates into bone and selectively inhibits osteoclast-mediated bone resorption in a dose-dependent manner. Some of these conditions are risk factors for osteonecrosis. When alendronate is used in fixed combination with cholecalciferol, consider the cautions, precautions, and contraindications associated with cholecalciferol. Lindsay R, Cosman F, Lobo RA et al. Addition of alendronate to ongoing hormone replacement therapy in the treatment of osteoporosis: a randomized, controlled clinical trial. J Clin Endocrinol Metab.
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But these events are more common in patients taking bisphosphonates than in patients taking other drugs. Products meeting necessary bioequivalence requirements. Calcium gluconate and calcium lactate. Because long-term safety is not yet established, it is only FDA-approved for 24 months of use. Safety labeling change and REMS notification. Silver Spring, MD; 2010 Oct 13. From FDA web site.
Ask your doctor or pharmacist about using this product safely. Are there any alternatives to the primary approach that you're suggesting? Alendronate has been used concomitantly with hormone replacement therapy. Prevent falls. Wear low-heeled shoes with nonslip soles and check your house for electrical cords, area rugs and slippery surfaces that might cause you to trip or fall. Keep rooms brightly lit, install grab bars just inside and outside your shower door, and make sure you can get into and out of your bed easily.
Caution is advised if you are or planning to become pregnant in the future. Alendronate may stay in your body for many years. Its effects on an unborn baby are unknown. Discuss the risks and benefits with your doctor before starting treatment with alendronate. However, there's no hard evidence that taking vitamin D prevents or treats any of these illnesses. Homik JE, Cranney A, Shea B et al. A metaanalysis on the use of bisphosphonates in corticosteroid induced osteoporosis. J Rheumatol. Women who took 5 milligrams daily had smaller gains. In patients with renal impairment, clearance of alendronate likely to be reduced. 1 112 Somewhat greater accumulation in bone expected.
Dr. Paula Rackoff, assistant chief of rheumatology and director of the Osteoporosis Center at Beth Israel Medical Center in New York City. Cleveland Clinic: "Temporomandibular Disorders. Do not take an alendronate tablet if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus the tube that connects your mouth and stomach. You will need to stay upright for at least 30 minutes after taking this medication. Ureteral spasm, spasm of vesicle sphincters and urinary retention have been reported with opiates.